extract of Glycyrrhiza glabra Linn. in aspirin induced ulcer in rats. . The aim of the study was to determine anti ulcer activity of stem bark of. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total Keywords: Anti-ulcer, Cold-restraint, Glycyrrhiza glabra, GutGardTM. The present research has been carried out to investigate antiulcer activity of ethanolic extract of Cynodon dactylon, Ocimum sanctum, Glycyrrhiza glabra, Ficus.
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M College of Pharmacy. The following scores were used: Review of Pharmacological Effects of Glycyrrhiza sp. In addition, the acute toxicity and LD 50 were evaluated. Peptic ulcer is a major gastro-intestinal disorder caused by an imbalance between offensive gastric acid, pepsinogen secretion and defensive mucous secretion, gastric mucosal integrity factors.
Anti-ulcer activity of aqueous and ethanolic extracts of Glycyrrhiza glabra L. in rats.
Gastric and duodenal peptic ulcers affect thousands of antiulcee and in the clinical practice are the most common gastrointestinal disorders. Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. The results indicated that G. Author information Article notes Copyright and License information Disclaimer. The number and severity of lesions were evaluated.
All chemicals and extract doses were prepared immediately before use. Principally glycyrrhizin reduces ROS generation which is the potent mediator of tissue inflammation.
Endogenous prostaglandins regulate mucosal blood flow, epithelial cell proliferation, epithelial restitution, mucosal immunocyte function, mucus and bicarbonate secretion, and basal acid secretion. Lgabra depletion of stomach wall mucus after oral ethanol administration has also been reported Hypothermic restraint stress ulcer The experiment was performed by the method of Sairam et al.
Ethanol and HCl are corrosive agents that damage the gastric mucosa. Memory enhancing activity of Glycyrrhiza acttivity in mice.
Anti Ulcer Activity Of Aloevera And Glycyrrhiza Glabra In Swiss Albino Rats |
Number of advantages are associated with use of herbal medicines as opposed to pharmaceutical products some of which include include reduced risk of side effects, effectives with chronic hlycyrrhiza, lower cost, widespread availability.
Currently, effective drugs exist for peptic ulcer diseases. Antiulcer activity of Sapindus saponaria L. The HEGG was effective in this model and this glycyrrrhiza may be due to increased mucus secretion that protects gastric mucosa from corrosive effects of ethanol.
The animals were randomly assigned to different groups. Several studies have indicated that Glycyrrhiza glabra extract or its derivatives, mainly glycyrrhizin, bear expectorant, diuretic, laxative, sedative, antipyretic, antimicrobial and anxiolytic, antiviral, anti-inflammatory and antioxidant activities 4.
Its pathogenesis is influenced by acid-pepsin secretion, cellular regeneration, mucus secretion, blood flow, mucosal barrier, prostaglandins, epidermal growth 5 and Helicobacter pylori infection 6. Support Center Support Center. Present study has evaluated the antiulcerogenic activity of Hydroalcoholic extract of licorice that grows in Iran. Home Publications Conferences Register Contact. Gastric contents and blood clots were removed then the stomach rinsed in formaldehyde and fixed between two glass plates.
Pre-treatment with omeprazole and HEGG were found to decrease the ethanol-induced gastric mucosal injuries.
Thereby it was reported, G. This effect could be related to an increase of gastric mucosal defensive factors. Increased macrophage glutathione content reduces cell-mediated oxidation of LDL and atherosclerosis in apolipoprotein E-deficient mice. Statistical analysis The experimental data were tested for statistical significance by means of analysis of variance with one-way classification.
Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats. To overcome the drawbacks, many experimental investigations 2357 have been undertaken to detect and develop ulcer healing agents by various plant origin compounds.
Gastric mucosal cellular changes induced by indomethacin male albino rats. Recently it was shown that licorice in a combination product could heal ulcers effectively 33 that strongly confirm results of this study. Thirty minutes after the administration of ethanol, the mice were killed by cervical dislocation, and the stomach was removed and opened along the greater curvature. Peptic ulcer disease caused 0. Anti-ulcer properties of saponins have been reported This also implies that the antiulcergenic activity afforded by HEGG may be associated with its antiinflamatory action, antioxidant actuvity, cytoprotective activity, and also due to increase in the prostaglandin formation.
The HEGG protected the stomachs of the mice from induced acute ulceration in various models and did not present activigy toxic effects, providing scientific support to the traditional use of this plant.